Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

217
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
217
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

364
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
364
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

832
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
832
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

417
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
417
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

449
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
449
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

1.2K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[History of pediatric nephrology in France].

Medecine sciences : M/S·2023
Same author

Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function.

The Journal of clinical investigation·2022
Same author

Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function.

The Journal of clinical investigation·2019
Same author

[Urinary tract infection in children].

La Revue du praticien·2018
Same author

Long-term successful liver-kidney transplantation in a child with atypical hemolytic uremic syndrome caused by homozygous factor H deficiency.

Pediatric nephrology (Berlin, Germany)·2016
Same author

Long-term results of combined liver-kidney transplantation for primary hyperoxaluria type 1: the French experience.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2014

Related Experiment Video

Updated: Dec 28, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

3.3K

Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure.

Albert Bensman1

  • 1Service de Nephrologie Pediatrique, Hopital Necker-Enfants Malades, Paris, France.

Frontiers in Pediatrics
|February 11, 2020
PubMed
Summary

Over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) pose risks for children, including acute kidney injury and chronic renal failure. Pediatric nephrologists should be aware of these potential adverse effects.

Keywords:
acute renal failurearachidonic acidinterstitial nephritisnon-steroidal anti-infammatory drugsprostaglandin E2volume depletion

More Related Videos

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.4K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.2K

Related Experiment Videos

Last Updated: Dec 28, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

3.3K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.4K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.2K

Area of Science:

  • Pediatric Nephrology
  • Pharmacology
  • Adverse Drug Events

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are widely available over-the-counter.
  • Their availability raises concerns for pediatric populations due to potential renal side effects.

Purpose of the Study:

  • To highlight the risks associated with over-the-counter NSAID use in children.
  • To inform pediatric nephrologists about NSAID-induced renal complications.

Main Methods:

  • Review of known adverse effects of NSAIDs in pediatric patients.
  • Analysis of mechanisms leading to renal injury from NSAIDs.

Main Results:

  • NSAIDs can cause acute renal failure via glomerular hypoperfusion, potentially leading to acute tubular necrosis.
  • Other risks include medullary ischemic injury, cardiovascular diseases, and interstitial nephritis, which can result in chronic renal failure.
  • Electrolyte abnormalities such as hyponatremia, hyperkaliemia, renal tubular acidosis, and hypertension due to fluid retention are also noted.

Conclusions:

  • The over-the-counter availability of NSAIDs presents significant risks for pediatric kidney health.
  • Awareness and careful consideration are crucial for managing NSAID use in children to prevent renal complications.