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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Radiotherapy for HCC: Ready for prime time?

Andrew Bang1, Laura A Dawson1

  • 1Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada, M5G 2C1.

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Summary

Stereotactic body radiation therapy (SBRT) offers durable local control for hepatocellular carcinoma (HCC) when other treatments fail. Further research is needed to solidify SBRT's role in HCC management and metastatic disease.

Keywords:
HCCHepatocellular carcinomaProtonsSBRTStereotactic body radiation therapy

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Area of Science:

  • Oncology
  • Radiotherapy
  • Hepatobiliary Malignancies

Background:

  • Stereotactic body radiation therapy (SBRT) is emerging as a valuable treatment for hepatocellular carcinoma (HCC).
  • Advances in imaging technology have enhanced the feasibility and efficacy of SBRT.
  • SBRT is often considered when other locoregional therapies are not suitable for HCC management.

Purpose of the Study:

  • To review the current evidence on SBRT for hepatocellular carcinoma (HCC).
  • To highlight considerations for SBRT in various HCC treatment settings.
  • To explore SBRT's potential role in managing extrahepatic metastatic HCC.

Main Methods:

  • Review of existing literature and clinical evidence regarding SBRT in HCC.
  • Analysis of SBRT's efficacy in primary HCC treatment, bridging, and downstaging.
  • Exploration of SBRT applications for oligo-metastatic disease.

Main Results:

  • SBRT demonstrates high rates of durable local control in HCC management.
  • Evidence supporting SBRT's definitive role in the HCC treatment paradigm is still developing.
  • SBRT shows promise in specific scenarios, including bridging and downstaging.

Conclusions:

  • SBRT is an effective option for HCC, particularly when other therapies are contraindicated.
  • Further investigation is required to establish SBRT's established position within the HCC treatment algorithm.
  • SBRT may offer a viable treatment strategy for select patients with metastatic HCC.