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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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Related Experiment Video

Updated: Dec 28, 2025

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Fast Imaging for Hyperpolarized MR Metabolic Imaging.

Jeremy W Gordon1, Hsin-Yu Chen1, Nicholas Dwork1

  • 1Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California, USA.

Journal of Magnetic Resonance Imaging : JMRI
|February 11, 2020
PubMed
Summary

Hyperpolarized carbon-13 MRI offers noninvasive metabolic imaging for various diseases. Fast imaging methods are crucial for capturing rapid metabolic changes and improving diagnostic capabilities in human studies.

Keywords:
chemical shift encodinghyperpolarized carbon-13metabolic imagingmetabolite-specific imagingreal-time calibrationspectroscopic imaging

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Area of Science:

  • Medical Imaging
  • Metabolic Imaging
  • Hyperpolarized Contrast Agents

Background:

  • Hyperpolarized carbon-13 (13C) agents enable noninvasive in vivo metabolic imaging.
  • This technique monitors key metabolic pathways by imaging substrates and products based on chemical shift.
  • Human studies are underway for cancer, heart, liver, and kidney diseases.

Purpose of the Study:

  • To review the state-of-the-art in fast imaging methods for hyperpolarized metabolic imaging.
  • To discuss the challenges and trade-offs of current fast imaging techniques.
  • To highlight advancements improving coverage, speed, SNR, resolution, and robustness.

Main Methods:

  • Focuses on three categories: fast spectroscopic imaging, model-based strategies, and metabolite-specific imaging.
  • Incorporates parallel imaging, compressed sensing, tailored RF flip angles, refocused imaging, and calibration methods.
  • Addresses the need for speed due to rapid decay of hyperpolarized agents and metabolic conversion.

Main Results:

  • Fast imaging methods are critical for capturing rapid metabolic conversions and agent decay.
  • Various techniques are employed to enhance scan speed, coverage, SNR, and resolution.
  • Initial human imaging results using these methods are highly promising.

Conclusions:

  • Advancements in fast imaging methods are essential for hyperpolarized metabolic MRI.
  • Improved methods will enhance coverage, SNR, resolution, and reproducibility in future human studies.
  • This technique holds significant promise for noninvasive diagnosis and monitoring of diseases.