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Updated: Dec 28, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors

Ana Luiza Ataide Carneiro de Paula Gonzaga1, Vitória Andrade Palmeira2, Thomas Felipe Silva Ribeiro2

  • 1Service of Pediatric Oncology, Clinics Hospital, Universidade Federal de Minas Gerais (UFMG), Brazil.

Current Drug Targets
|February 11, 2020
PubMed
Abstract

Insights

The Renin-Angiotensin System (RAS) alternative axis, particularly Angiotensin-(1-7), shows anti-tumor potential in various cancers. However, its efficacy in pediatric tumors requires further clinical investigation for safety and therapeutic targeting.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Pediatric tumors are a leading cause of death, necessitating novel, less toxic therapies.
  • The Renin-Angiotensin System (RAS), with its classical (ACE/Ang II/AT1R) and alternative (ACE2/Ang-(1-7)/MasR) axes, is implicated in cancer.
  • Investigating RAS in pediatric cancer offers potential for new therapeutic strategies.

Purpose of the Study:

  • To review the pathophysiological role of RAS in cancer.
  • To summarize evidence on the anti-tumor effects of the ACE2/Angiotensin-(1-7)/Mas receptor axis.
  • To explore future therapeutic perspectives for pediatric cancer.

Main Methods:

  • Comprehensive literature search of PubMed, Scopus, and SciELO databases.
  • Inclusion of studies on RAS molecules in human and pediatric cancers.
  • Keywords: RAS, ACE, Angiotensin-(1-7), ACE2, Angiotensin II, AT1 receptor, Mas receptor, Pediatric, Cancer.

Main Results:

  • Angiotensin-(1-7) demonstrated inhibition of tumor cell growth, inflammation, and angiogenesis in experimental models.
  • Clinical trials with Angiotensin-(1-7) (TXA127) showed promise but are insufficient for clinical recommendation.
  • Limited research exists on RAS in pediatric cancer, with no studies evaluating the alternative RAS axis.

Conclusions:

  • Angiotensin-(1-7) holds potential for pediatric tumor treatment but has not been tested in this population.
  • Further clinical trials, including pediatric patients, are essential to establish safety and efficacy.
  • Defining specific therapeutic targets for the alternative RAS axis in pediatric cancer is crucial.
Keywords:
ACE2Renin-angiotensin systemangiogenesisangiotensin IIangiotensin-(1-7)angiotensin-converting enzymecancerpediatric tumor

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