Recent Advances in Self-Assembled Nanoparticles for Drug Delivery

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Bulk materials aggregate to form nanoparticles with emergent properties distinct from their constituents.
• Self-assembled nanoparticles, including micelles and liposomes, are complex functional units formed from individual components.
• The self-assembly process is of increasing interest for controlling nanoparticle structure and properties.

Purpose of the Study:

• To review strategies for fabricating self-assembled nanoparticles.
• To discuss the properties associated with self-assembled nanoparticles.
• To explore the therapeutic applications of self-assembled nanoparticles.

Main Methods:

• This review synthesizes information on nanoparticle self-assembly strategies.
• It examines the physicochemical properties of self-assembled nanoparticles.
• Applications in therapy are discussed based on existing literature.

Main Results:

• Self-assembly enables control over nanoparticle structure and function.
• These nanoparticles offer enhanced drug delivery, bioavailability, and targeted action.
• They provide protection for encapsulated drugs and overcome physiological barriers.

Conclusions:

• Self-assembled nanoparticles represent a versatile platform for drug delivery and therapy.
• Their unique properties facilitate overcoming biological barriers and improving therapeutic outcomes.
• Further research into fabrication strategies and applications holds significant promise.