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Biological performance of TiNi shape memory alloy vascular ring prostheses: a two year study
The International Journal of Artificial Organs
|November 1, 1988
Summary
A novel noninvasive method for inserting vascular ring prostheses demonstrated high patency rates in canine arteries. This technique shows promise for preventing restenosis after angioplasty and treating atherosclerosis.
Area of Science:
- Biomedical Engineering
- Vascular Surgery
- Materials Science
Background:
- Recurrent stenosis after angioplasty remains a clinical challenge.
- Existing treatments often fail to prevent arterial narrowing during the healing phase.
Purpose of the Study:
- To develop and evaluate a noninvasive method for vascular ring prosthesis insertion.
- To assess the long-term patency and biocompatibility of nitinol prostheses in canine arteries.
Main Methods:
- A custom 7F catheter was used to deploy nitinol (TiNi) wire prostheses (5 mm I.D., 0.25 mm thickness) into carotid and iliac-femoral arteries of dogs.
- Prostheses were inserted noninvasively under fluoroscopic guidance.
- Animals received aspirin and Persantin for 30 days postoperatively.
Main Results:
- Angiography at 1, 6, and 12 months showed 91% (20/22) long-term patency.
- Four prostheses in iliac and femoral arteries maintained 100% patency for up to 2 years.
- Stable anchorage and uniform neointimal coverage with endothelial-like cells were observed, with no thrombosis or inflammation.
Conclusions:
- The developed noninvasive insertion method for vascular ring prostheses is safe and effective.
- Nitinol prostheses exhibit excellent biocompatibility and long-term patency, preventing restenosis.
- This approach offers a potential new clinical intervention for atherosclerosis and post-angioplasty restenosis.