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Related Experiment Video

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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
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Novel approach towards musculoskeletal phenotypes.

Ingebrigt Meisingset1, Ottar Vasseljen1, Nina K Vøllestad2

  • 1Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

European Journal of Pain (London, England)
|February 11, 2020
PubMed
Summary

This study identified five distinct patient phenotypes for common musculoskeletal pain based on biopsychosocial factors. These phenotypes show varied treatment outcomes, suggesting a need for targeted interventions in musculoskeletal disorders.

Keywords:
biopsychosocialmusculoskeletal painprognosissubgrouping

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Area of Science:

  • Musculoskeletal health
  • Pain management
  • Biopsychosocial research

Background:

  • Optimizing management for musculoskeletal pain is challenging due to patient heterogeneity.
  • Clinical features and prognostic factors vary widely.
  • A need exists to understand this heterogeneity for better treatment.

Purpose of the Study:

  • To identify distinct patient phenotypes in common musculoskeletal pain.
  • To analyze phenotypes based on biopsychosocial prognostic factors.
  • To assess the validity and treatment outcomes of identified phenotypes.

Main Methods:

  • A longitudinal observational study of 435 patients with nonspecific musculoskeletal complaints.
  • Latent class analysis used to identify phenotypes based on 11 prognostic factors across four biopsychosocial domains.
  • Concurrent and external validity assessed, and treatment outcomes described.

Main Results:

  • Five distinct phenotypes were identified, varying in biopsychosocial domain scores.
  • Phenotypes showed good external and concurrent validity.
  • Significant differences in function and quality of life outcomes were observed across phenotypes at 3-month follow-up.

Conclusions:

  • Identified phenotypes are clinically meaningful and independent of primary pain location.
  • Findings highlight patient heterogeneity in musculoskeletal pain.
  • Phenotypes can inform the development of targeted interventions to improve treatment efficiency.