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Updated: Dec 28, 2025
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Published on: February 28, 2018
Reference intervals of mesenteric lymph node size according to lymphocyte counts in asymptomatic children
Baohuan Cai1, Huiming Yi2, Wei Zhang2
1Department of pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province, China.
This study establishes reference intervals for mesenteric lymph node size in children, finding a correlation with lymphocyte counts. A short-axis diameter over 8-10 mm suggests mesenteric lymphadenitis.
Area of Science:
- Pediatric Radiology
- Lymphatic System Imaging
- Diagnostic Criteria Development
Background:
- The reference interval for mesenteric lymph node size in healthy children is not established.
- The size criterion for mesenteric lymph node enlargement (MLNE) is controversial.
Purpose of the Study:
- To explore reference intervals of mesenteric lymph node size based on lymphocyte counts in asymptomatic children.
- To develop a more appropriate definition for MLNE.
Main Methods:
- Asymptomatic children were divided into five age strata (2-7 years).
- Correlation analyses were performed between lymphocyte counts and largest mesenteric lymph node (LMLN) dimensions.
- Reference intervals for LMLN short-axis diameter and lymphocyte counts were established per age group.
Main Results:
- Significant correlations were found between LMLN short-axis diameter and lymphocyte counts across all age and gender groups.
- The overall reference interval for LMLN short-axis diameter in children was 0.54 cm-1.03 cm (mean 0.75 cm).
Conclusions:
- The study supports using a short-axis diameter >8-10 mm for diagnosing primary mesenteric lymphadenitis.
- This criterion should be applied when three or more mesenteric lymph nodes are present without other abnormalities.
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