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Nonlinear viscoelastic constitutive model for bovine liver tissue
Adela Capilnasiu1, Lynne Bilston2,3, Ralph Sinkus4,5
1Division of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. adela.capilnasiu@kcl.ac.uk.
Biomechanics and Modeling in Mechanobiology
|February 11, 2020
Summary
This study defines a liver constitutive equation for nonlinear viscoelastic behavior. This model aids in understanding liver tissue mechanics for injury diagnosis and device design.
Area of Science:
- Biomechanics
- Biomaterials Science
- Medical Engineering
Background:
- Soft tissue mechanical characterization is crucial for medical research, including surgery, device design, injury assessment, and disease diagnosis.
- The liver is frequently injured in accidents and assessed for chronic diseases, highlighting the need for its biomechanical understanding.
Purpose of the Study:
- To define a liver constitutive equation for characterizing nonlinear viscoelastic behavior.
- To model liver tissue response across various deformations and frequencies.
Main Methods:
- Utilized viscoelastic-adapted Mooney-Rivlin, Ogden, and exponential models.
- Modeled tissue response to large amplitude oscillatory shear (1-50%) under varying preloads (1-20%) and frequencies (0.5-2 Hz).
- Applied classical or modified objective norms for model fitting.
Main Results:
- All three models effectively captured the initial nonlinear regime of liver tissue.
- The Ogden and exponential models simultaneously characterized the entire tested deformation range.
- Identified a constitutive equation describing liver's nonlinear viscoelastic behavior.
Conclusions:
- The developed constitutive equation provides a comprehensive description of liver tissue's nonlinear viscoelastic properties.
- This research advances biomechanical modeling for liver applications in medicine and engineering.
- Findings support improved surgical planning, device development, and injury analysis related to the liver.
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