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Updated: Dec 28, 2025

High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT
Published on: June 21, 2011
Physical evaluation of an ultra-high-resolution CT scanner
Luuk J Oostveen1, Kirsten L Boedeker2, Monique Brink3
1Department of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101 (Route 766), 6500 HB, Nijmegen, The Netherlands. Luuk.Oostveen@radboudumc.nl.
Objectives:
To evaluate the technical performance of an ultra-high-resolution CT (UHRCT) system.
Methods:
The physico-technical capabilities of a novel commercial UHRCT system were assessed and compared with those of a current-generation multi-detector (MDCT) system. The super-high-resolution (SHR) mode of the system uses 0.25 mm (at isocentre) detector elements (dels) in the in-plane and longitudinal directions, while the high-resolution (HR) mode bins two dels in the longitudinal direction. The normal-resolution (NR) mode bins dels 2 × 2, resulting in a del-size equivalent to that of the MDCT system. In general, standard procedures and phantoms were used to perform these assessments.
Results:
The UHRCT MTF (10% MTF 4.1 lp/mm) is twice as high as that of the MDCT (10% MTF 1.9 lp/mm), which is comparable to the MTF in the NR mode (10% MTF 1.7 lp/mm). The width of the slice sensitivity profile in the SHR mode (FWHM 0.45 mm) is about 60% of that of the MDCT (FWHM 0.77 mm). Uniformity and CT numbers are within the expected range. Noise in the high-resolution modes has a higher magnitude and higher frequency components compared with MDCT. Low-contrast visibility is lower for the NR, HR and SHR modes compared with MDCT, but about a 14%, for NR, and 23%, for HR and SHR, dose increase gives the same results.
Conclusions:
HR and SHR mode scanning results in double the spatial resolution, with about a 23% increase in dose required to achieve the same low-contrast detectability.
Key Points:
• Resolution on UHRCT is up to twice as high as for the tested MDCT. • With abdominal settings, UHRCT needs higher dose for the same low-contrast detectability as MDCT, but dose is still below achievable levels as defined by current diagnostic reference levels. • The UHRCT system used in normal-resolution mode yields comparable resolution and noise characteristics as the MDCT system.
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