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Related Concept Videos

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Autism Spectrum Disorder

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Related Experiment Video

Updated: Dec 28, 2025

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
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Pain Modulation Mechanisms in ASD Adults.

A Dubois1,2,3, M Boudjarane4, A Le Fur-Bonnabesse4

  • 1LP3C - EA1285, Department of Psychology, University of Western Brittany, Brest, France. amandine.dubois@univ-brest.fr.

Journal of Autism and Developmental Disorders
|February 11, 2020
PubMed
Summary

Adults with autism spectrum disorder (ASD) show similar pain modulation to neurotypical individuals. However, pain scores in the ASD group were highly variable, indicating a need for careful interpretation of results.

Keywords:
AutismCPMExperimental painPain modulationTemporal summation

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Area of Science:

  • Neuroscience
  • Psychology
  • Autism Spectrum Disorders Research

Background:

  • Understanding endogenous pain modulation is crucial for pain management.
  • Autism Spectrum Disorders (ASD) may involve atypical sensory processing, including pain perception.
  • Previous research has shown varied results regarding pain modulation in ASD.

Purpose of the Study:

  • To investigate endogenous pain modulation mechanisms in adults with Autism Spectrum Disorders (ASD).
  • To compare pain processing in adults with ASD to neurotypical controls.
  • To identify potential differences in excitatory and inhibitory pain mechanisms.

Main Methods:

  • Recruited 19 adults with ASD (without intellectual disabilities) and 19 matched neurotypical controls.
  • Utilized an experimental pain model to assess pain modulation.
  • Measured both excitatory and inhibitory pain mechanisms within a single session.

Main Results:

  • No significant differences were found in endogenous pain modulation mechanisms between the ASD and control groups.
  • Pain scores exhibited greater variability and a wider range of extreme scores in the ASD group compared to controls.
  • No systematic dysfunction in endogenous excitatory pain modulation was observed in ASD, unlike in schizophrenia.

Conclusions:

  • Endogenous pain modulation appears largely intact in adults with ASD.
  • The high variability in pain scores within the ASD group necessitates cautious interpretation of findings.
  • Further research is needed to understand the implications of heightened pain score variability in ASD.