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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Introduction to Fibroblasts01:09

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Fibroblasts in the Tumor Microenvironment.

Marta Truffi1,2, Luca Sorrentino2, Fabio Corsi3,4

  • 1Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.

Advances in Experimental Medicine and Biology
|February 11, 2020
PubMed
Summary

Cancer-associated fibroblasts within the tumor microenvironment drive tumor progression by altering tissue structure and suppressing immune responses. Understanding these fibroblasts is key for developing new cancer therapies targeting the tumor microenvironment.

Keywords:
Cancer treatmentCancer-associated fibroblastsCancer-stroma crosstalkChemoresistanceEpithelial-to-mesenchymal transitionExtracellular matrix remodelingImmunosuppressionPro-tumorigenic cytokinesTargeted therapyTumor microenvironmentTumor neoangiogenesis

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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

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Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • The tumor microenvironment plays a critical role in cancer initiation and progression.
  • Fibroblasts are a major cell type in the tumor stroma, producing key extracellular components.
  • Quiescent fibroblasts can transform into cancer-associated fibroblasts, promoting tumor growth.

Purpose of the Study:

  • To investigate the role of cancer-associated fibroblasts in shaping the tumor microenvironment.
  • To understand how cancer-associated fibroblasts contribute to tumor progression and immune suppression.
  • To explore cancer-associated fibroblasts as potential therapeutic targets.

Main Methods:

  • Analysis of fibroblast populations within the tumor stroma.
  • Characterization of extracellular matrix remodeling.
  • Assessment of immune response modulation by cancer-associated fibroblasts.

Main Results:

  • Cancer-associated fibroblasts secrete pro-tumorigenic signals.
  • These signals remodel tissue architecture and suppress local immune responses.
  • Fibroblast heterogeneity contributes to diverse pro-tumorigenic functions.

Conclusions:

  • Cancer-associated fibroblasts are crucial drivers of tumor progression.
  • Targeting cancer-associated fibroblasts may offer novel therapeutic strategies.
  • Further research into fibroblast heterogeneity is warranted for effective cancer treatment.