Current Biomedical Use of Copper Chelation Therapy
Silvia Baldari1,2, Giuliana Di Rocco1, Gabriele Toietta1
1Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, via E. Chianesi 53, 00144 Rome, Italy.
International Journal of Molecular Sciences
|February 12, 2020
Summary
Maintaining balanced copper levels is crucial for health. This review covers diseases linked to excess copper and explores promising copper chelating agents used in clinical trials.
Area of Science:
- Biochemistry
- Pathology
- Pharmacology
Background:
- Copper is an essential trace element vital for numerous biological functions.
- Disruptions in copper homeostasis are implicated in various diseases, including Wilson's syndrome, neurodegenerative disorders (Alzheimer's, Parkinson's), pulmonary fibrosis, diabetes, and cancers.
- Pathological copper accumulation contributes significantly to disease pathogenesis.
Purpose of the Study:
- To review disorders associated with elevated copper levels.
- To summarize the efficacy of copper chelating agents in managing copper homeostasis deregulation.
- To highlight compounds evaluated in clinical trials for copper-related conditions.
Main Methods:
- Literature review of scientific articles and clinical trial data.
- Focus on compounds experimentally and clinically evaluated for copper-chelating properties.
- Synthesis of information on diseases and therapeutic strategies.
Main Results:
- Identified key diseases linked to copper dysregulation.
- Detailed the mechanisms of action for various copper chelating agents.
- Summarized the clinical outcomes and potential of different therapeutic approaches.
Conclusions:
- Copper chelating agents represent a promising therapeutic strategy for managing diseases of copper excess.
- Further research and clinical evaluation are essential to optimize copper-chelating therapies.
- Effective regulation of copper homeostasis is critical for preventing and treating a spectrum of human diseases.
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