Microassay for adenosine deaminase, the enzyme lacking in some forms of immunodeficiency, in mouse preimplantation

¹MRC Mammalian Development, University College London, UK.

|November 1, 1988

Abstract:

A highly sensitive biochemical microassay has been developed for adenosine deaminase (ADA; EC 3.5.4.4), the enzyme deficient in approximately 20% of cases of severe combined immuno-deficiency disease (SCID). The microassay is capable of detecting femtomolar amounts of reaction product in a single blastomere from a mouse 8-cell embryo and thus is sensitive enough to be considered for the possible preimplantation diagnosis of SCID in human embryos.

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