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Related Experiment Video

Updated: Dec 28, 2025

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The cure model in perinatal epidemiology.

Emil A Stoltenberg1,2, Hedvig Me Nordeng2,3,4, Eivind Ystrom2,3,4,5

  • 1Department of Mathematics, University of Oslo, Oslo, Norway.

Statistical Methods in Medical Research
|February 12, 2020
PubMed
Summary

Cure models offer a robust statistical framework for perinatal epidemiology, particularly for long-term outcomes like attention-deficit hyperactivity disorder (ADHD) following gestational exposures. This approach correctly analyzes outcomes detectable years after birth, enhancing research accuracy.

Keywords:
Cox regressionPerinatal epidemiologyattention-deficit hyperactivity disordercensoringfrailty modellogistic regressionmother–child studiesparacetamol

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Area of Science:

  • Perinatal Epidemiology
  • Biostatistics
  • Developmental Psychology

Background:

  • Cure models are increasingly recognized in statistical literature.
  • These models are underutilized in perinatal epidemiology.
  • Perinatal studies often involve long-term outcomes that are difficult to ascertain.

Purpose of the Study:

  • To demonstrate the utility of cure models in perinatal epidemiology.
  • To provide a statistical framework for analyzing gestational exposures and long-term health conditions.
  • To illustrate the application of cure models using a real-world example.

Main Methods:

  • Application of cure models to analyze longitudinal data.
  • Viewing long-term health outcomes as censored binary variables.
  • Utilizing data from the Norwegian Mother, Father and Child Cohort Study and the Norwegian Patient Registry.

Main Results:

  • Cure models provide a suitable statistical framework for perinatal epidemiological studies.
  • The analysis demonstrated a potential link between gestational paracetamol exposure and attention-deficit hyperactivity disorder.
  • The study highlights the importance of appropriate statistical methods for long-term outcome assessment.

Conclusions:

  • Cure models are essential for perinatal epidemiologists studying long-term effects of gestational exposures.
  • This statistical approach can improve the understanding of developmental disorders like ADHD.
  • Further research using cure models is recommended for perinatal health studies.