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Spontaneous hydronephrosis in C57BL/KsJ mice.
1Department of Pathology, Washington University School of Medicine, St Louis, MO 63110.
Journal of Comparative Pathology
|November 1, 1988
Summary
Spontaneous hydronephrosis was observed in C57BL/KsJ mice, a rare condition in this strain. The cause is likely a novel mutation or a long-standing multigenic trait, as skeletal defects were absent.
Area of Science:
- Veterinary Pathology
- Genetics
- Developmental Biology
Background:
- Spontaneous hydronephrosis is a rare condition in laboratory mice.
- Previous reports link mouse hydronephrosis to specific mutations often accompanied by skeletal defects.
- This condition has not been previously documented in the C57BL/KsJ mouse strain.
Purpose of the Study:
- To describe the gross and histological features of spontaneous hydronephrosis in C57BL/KsJ mice.
- To investigate the potential cause of hydronephrosis in this strain, differentiating it from known mutations.
Main Methods:
- Necropsy of 33 C57BL/KsJ mice.
- Gross examination of observed lesions.
- Histological analysis of affected tissues.
Main Results:
- Spontaneous hydronephrosis was identified in 15 out of 33 necropsied mice.
- Detailed gross and histological descriptions of the hydronephrotic kidneys were recorded.
- No skeletal malformations were observed in any of the affected mice.
Conclusions:
- The observed hydronephrosis in C57BL/KsJ mice is likely due to a genetic factor distinct from previously identified mutations.
- A long-standing, variably expressed multigenic trait or a novel mutation is suspected as the underlying cause.
- Further genetic investigation is warranted to elucidate the etiology of hydronephrosis in this mouse model.