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Digital ischaemia secondary to adalimumab-induced antiphospholipid syndrome

Shashank Cheemalavagu1, Sara S McCoy2, Jason S Knight3

  • 1Internal Medicine, University of Michigan Hospital, Ann Arbor, Michigan, USA.

BMJ Case Reports
|February 12, 2020
PubMed

A 50-year-old woman with a history of Crohn's disease treated with adalimumab presented with left hand pain and duskiness. Angiogram showed non-filling of the radial and digital arteries of the hand. Antiphospholipid antibody testing was positive, leading to a diagnosis of antitumour necrosis factor-induced antiphospholipid syndrome. Adalimumab was discontinued, and she was treated with the vitamin K antagonist warfarin and low-dose aspirin. Upon resolution of the antiphospholipid antibodies, she was transitioned to aspirin alone without recurrence of thrombosis.

Keywords:
biological agentssystemic lupus erythematosus

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