Related Experiment Video
Updated: Dec 28, 2025
10:14
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
4.1K
Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children
In Jeong Lyu1,2, Kyung-Ah Park1, Sei Yeul Oh3
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Scientific Reports
|February 12, 2020
Summary
Peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children are linked to myopia. Optic nerve head tilt may mediate the relationship between myopia and PHOMS.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Medical Imaging
Background:
- Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are observed in children's eyes.
- Understanding the characteristics and risk factors of PHOMS is crucial for pediatric eye health.
Purpose of the Study:
- To investigate the characteristics of children with PHOMS.
- To evaluate the risk factors associated with the presence of PHOMS in children.
Main Methods:
- A cross-sectional study involving 66 children with PHOMS and 46 controls.
- Disc enhanced-depth image spectral-domain (SD) optical coherence tomography (OCT) was used for assessment.
- Univariable and multivariable logistic regression analyses were performed to identify risk factors.
Main Results:
- Children with PHOMS exhibited a significant myopic shift (mean spherical equivalent -3.13 D) compared to controls (-0.95 D).
- Optic nerve head (ONH) tilt angle was significantly greater in the PHOMS group (9.84 degrees) versus controls (3.71 degrees).
- Both spherical equivalent (SE) and ONH tilt angle were significantly associated with PHOMS, with SE and ONH tilt showing a significant negative correlation.
Conclusions:
- PHOMS in children are associated with a myopic shift.
- Optic disc tilt may act as a mediator in the relationship between myopia and the development of PHOMS.
