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The giant aggressive chondroma: A rare entity, a difficult approach
Carmine Zoccali1, Jacopo Baldi1, Vincenzo Anelli2
1Oncological Orthopaedics Department, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
Introduction:
enchondromas rarely exceed 3-6 cm in long bones. Although the risk of developing secondary chondrosarcoma has been reported up to 4% in solitary lesions, it is not known if size represents a risk factor for transformation.
Objective:
to describe three exceptional cases of enchondromas of the entire femur whereof one dedifferentiated in chondrosarcoma.
Results:
two patients present stable disease at 5 and 6 years of follow-up; the third, already diagnosed with a dedifferentiated chondrosarcoma, died 14 months after the index surgery for systemic disease.
Conclusion:
based on these observations, our hypothesis is that lesion size is an important risk factor for malignant transformation.
