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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

5.9K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Need of vascular surgeon and comparison of value for anterior lumbar interbody fusion (ALIF) in lateral decubitus: Delphi consensus.

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A rare case of bilateral occipital condyle fractures associated with inferior clivus separation fracture resulting in craniocervical dislocation: a case report and modification of the Anderson and Montesano classification is proposed.

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Lengthening Nails for Distraction Osteogenesis: A Review of Current Practice and Presentation of Extended Indications.

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Extreme lateral interbody fusion relieves symptoms of spinal stenosis and low-grade spondylolisthesis by indirect decompression in complex patients.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2016
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Cervical synovial cyst.

British journal of neurosurgery·2014
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Are intraspinal anomalies in early onset idiopathic scoliosis as common as once thought? A two centre United Kingdom study.

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Real-world outcomes of minimally invasive posterior thoracic and lumbar spine fusion surgery versus open surgery in the Finnish Spine Registry.

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Defining spine care: a framework for scope, standards, and bidirectional care transitions.

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Interlaminar versus sublaminar lumbar decompression: a retrospective study on patient satisfaction as measured by PROMIS outcomes.

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L5/S1 anterior lumbar interbody fusion: anatomical and technical considerations.

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Related Experiment Video

Updated: Dec 28, 2025

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
10:49

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

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Stem cell therapy in discogenic back pain.

Ahmed H Barakat1, Vivian A Elwell1, Khai S Lam2

  • 1Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.

Journal of Spine Surgery (Hong Kong)
|February 12, 2020
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for treating chronic low back pain by regenerating intervertebral discs. Further clinical studies are needed to confirm the safety and effectiveness of this emerging regenerative medicine approach.

Keywords:
Stem cell transplantationintervertebral disc degenerationlow back painregenerative medicinetissue scaffolds

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Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
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Area of Science:

  • Regenerative Medicine
  • Orthopedics
  • Biotechnology

Background:

  • Chronic low back pain significantly impacts patients and healthcare systems.
  • Current treatments for discogenic low back pain often fall short of patient expectations.
  • Identifying the precise causes of disc degeneration remains challenging with existing diagnostic methods.

Purpose of the Study:

  • To explore stem cell therapy as a novel treatment for degenerative disc disease (DDD).
  • To review recent in vivo and in vitro studies on stem cell applications for discogenic pain.
  • To highlight the importance of patient selection and optimizing stem cell culturing for regenerative potential.

Main Methods:

  • Literature review of in vivo and in vitro studies.
  • Analysis of stem cell sources (autogenic, allogenic, primary disc cells).
  • Examination of the role of the stem cell microenvironment, culturing techniques, delivery vehicles, and scaffolds.

Main Results:

  • Stem cell therapy aims to restore disc cellularity and modulate inflammation.
  • The culture microenvironment is critical for directing stem cell phenotype and regenerative capacity.
  • Various stem cell sources and delivery methods are being investigated.

Conclusions:

  • Stem cell therapy presents a potential alternative for treating degenerative disc disease and chronic low back pain.
  • Optimizing culturing techniques, delivery systems, and scaffolds is key to enhancing regenerative potential.
  • More clinical research is essential to establish the safety and feasibility of stem cell treatments for discogenic pain.