Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

281
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
281
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

490
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
490
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

243
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
243
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

481
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
481
Nephrons01:10

Nephrons

6.0K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.0K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

228
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
228

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis, Education, and Care of Patients with <i>APOL1</i>-Associated Nephropathy: A Delphi Consensus and Systematic Review.

Journal of the American Society of Nephrology : JASN·2021
Same author

Cardiovascular and Renal Outcomes in Patients with Type-2 Diabetes and Chronic Kidney Disease Identified in a United States Administrative Claims Database: A Population Cohort Study.

Nephron·2021
Same author

The Impact of RDNs on Non-Communicable Diseases: Proceedings from The State of Food and Nutrition Series Forum.

Journal of the Academy of Nutrition and Dietetics·2021
Same author

Alignment of diagnosis and pharmacy claims data coding of medication adherence among patients with diabetes or hypertension.

Journal of managed care & specialty pharmacy·2021
Same author

Potassium Trajectories prior to Dialysis and Mortality following Dialysis Initiation in Patients with Advanced CKD.

Nephron·2021
Same author

Dietary protein intake, kidney function, and survival in a nationally representative cohort.

The American journal of clinical nutrition·2021

Related Experiment Video

Updated: Dec 28, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.4K

Constipation in CKD.

Keiichi Sumida1, Kunihiro Yamagata2, Csaba P Kovesdy1,3

  • 1Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Kidney International Reports
|February 12, 2020
PubMed
Summary
This summary is machine-generated.

Constipation is common in chronic kidney disease (CKD) and linked to worse outcomes. New treatments may offer kidney benefits beyond symptom relief.

Keywords:
cardiovascular diseasechronic kidney diseaseconstipationend-stage renal diseasegut microbiotalaxative

More Related Videos

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.6K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Related Experiment Videos

Last Updated: Dec 28, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.4K
Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.6K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Area of Science:

  • Nephrology
  • Gastroenterology
  • Microbiome Research

Background:

  • Constipation is highly prevalent in chronic kidney disease (CKD) patients due to lifestyle, diet, medications, and comorbidities.
  • Constipation is often underestimated but significantly impacts quality of life and is linked to adverse outcomes like end-stage renal disease, cardiovascular disease, and mortality.
  • The gut plays a crucial role in CKD, and constipation may impair its functions, potentially increasing morbidity and mortality.

Purpose of the Study:

  • To review the current understanding of constipation in CKD, including diagnosis, prevalence, etiology, outcomes, and treatment.
  • To discuss the novel clinical and therapeutic implications of managing constipation in CKD patients.
  • To highlight the potential renoprotective effects of new constipation pharmacotherapies.

Main Methods:

  • Literature review of epidemiological studies and recent evidence on constipation in CKD.
  • Analysis of the association between constipation and clinical outcomes in CKD.
  • Exploration of the role of gut microbiota and fecal metabolites in CKD-related constipation.

Main Results:

  • Constipation is an independent risk factor for adverse outcomes in CKD, including end-stage renal disease, cardiovascular disease, and mortality.
  • Gut microbiota alterations and increased fecal metabolites may mediate the negative effects of constipation in CKD.
  • Emerging pharmacologic agents for constipation show potential renoprotective properties.

Conclusions:

  • Constipation in CKD is underrecognized and inadequately managed, despite its significant impact on patient outcomes.
  • Effective management of constipation in CKD may offer benefits beyond symptom control, including potential renoprotection.
  • Further research and clinical attention are needed to address constipation in CKD effectively.