Related Experiment Video

Updated: Dec 28, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

702

Association of metabolic syndrome with pediatric psoriasis: a case-control study in Kabul, Afghanistan

Ahmad Khalid Aalemi1,2, Abdul Ghafar Hamdard3, Hongxiang Chen1

  • 1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

International Journal of Dermatology
|February 12, 2020
PubMed

Insights

Children with psoriasis face a higher risk of metabolic syndrome and cardiovascular issues. This study highlights the importance of monitoring these metabolic risks in pediatric psoriasis patients.

Area of Science:

  • Dermatology
  • Pediatrics
  • Metabolic Health

Background:

  • Pediatric psoriasis is increasingly recognized, yet its association with metabolic syndrome remains understudied.
  • Limited research exists on the prevalence of metabolic syndrome and obesity in children with psoriasis, particularly in Afghanistan.

Purpose of the Study:

  • To investigate the association between pediatric psoriasis and the risk of developing metabolic syndrome.
  • To assess the prevalence of obesity and cardiovascular risk factors in children with psoriasis compared to controls.

Main Methods:

  • A case-control study involving 113 children with psoriasis and 113 controls under 18 years old.
  • Measurements included height, weight, waist circumference, blood pressure, and fasting serum levels of glucose, triglycerides, cholesterol, and HDL.
  • Statistical analyses utilized Chi-square and independent t-tests, with odds ratios and 95% confidence intervals calculated.

Main Results:

  • Children with psoriasis showed significantly higher rates of overweight/obesity (27.4% vs. 12.4%) and central adiposity (23% vs. 9.7%).
  • The prevalence of metabolic syndrome was substantially greater in the pediatric psoriasis group (13.3% vs. 2.3%).
  • A family history of skin disorders was also more common in children with psoriasis (23.0% vs. 13.7%).

Conclusions:

  • Pediatric psoriasis is significantly associated with an increased risk of metabolic syndrome.
  • Children diagnosed with psoriasis exhibit a higher likelihood of presenting with cardiovascular risk factors and obesity.
Abstract

More Related Videos

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.4K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K

Related Concept Videos

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
3.4K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
402
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
146
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
643