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Related Experiment Video

Updated: Dec 28, 2025

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
08:09

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Selective extinction through cognitive evaluation: Linking emotion regulation and extinction.

Birthe Macdonald1,2, Shannon Wake1, Tom Johnstone1,3

  • 1University of Reading, Reading, UK.

The European Journal of Neuroscience
|February 12, 2020
PubMed
Summary

Cognitive evaluation shapes learned fear responses. A new task shows that evaluating information allows individuals to selectively reduce conditioned fear, engaging specific brain networks for decision-making.

Keywords:
cognitive reappraisalfMRIfear conditioningskin conductance

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Learned fear responses (conditioned responses) can be modified by cognitive processes.
  • Selective extinction allows for targeted reduction of fear based on evaluated information.

Purpose of the Study:

  • Introduce and validate a selective extinction through cognitive evaluation (SECE) task.
  • Investigate the neural mechanisms underlying cognitive modulation of conditioned fear extinction.

Main Methods:

  • Developed the SECE task involving conditioned stimuli (CS+/CS-) presented within categorized words.
  • Measured skin conductance responses and used functional magnetic resonance imaging (fMRI) to assess brain activity.
  • Compared SECE task activation with a cognitive reappraisal task.

Main Results:

  • Participants showed reduced fear responses to safe (COG-_CS+) versus risky (COG+_CS+) trials.
  • Distinct brain activation patterns were observed, with insula and ACC for risky trials, and frontal, temporal, and parietal regions for safe trials.
  • No direct overlap in brain activation between SECE and cognitive reappraisal tasks in voxelwise analysis, but shared lateral prefrontal mechanisms in ROI analyses.

Conclusions:

  • The SECE task effectively demonstrates cognitive modulation of conditioned fear extinction.
  • Semantic processing and decision-making are crucial for evaluating extinction contingencies.
  • While distinct, SECE and cognitive reappraisal may share underlying lateral prefrontal mechanisms.