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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open-angle
Naoki Kiyota1, Yukihiro Shiga1,2, Masayuki Yasuda1
1Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Acta Ophthalmologica
|February 12, 2020
Summary
Reduced optic nerve head tissue vasoreactivity, measured by laser speckle flowgraphy, is linked to faster glaucoma progression. This suggests potential biomarkers for predicting disease advancement.
Area of Science:
- Ophthalmology
- Medical Imaging
- Cardiovascular Physiology
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Visual field defect progression is a key indicator of glaucoma severity.
- Optic nerve head (ONH) blood flow is crucial for retinal ganglion cell survival.
Purpose of the Study:
- To investigate the relationship between ONH tissue vasoreactivity and the progression of visual field defects in glaucoma patients.
- To determine if laser speckle flowgraphy can identify biomarkers for glaucoma progression.
Main Methods:
- A prospective, longitudinal study of 28 eyes from 16 open-angle glaucoma patients.
- Oxygen inhalation testing with laser speckle flowgraphy to measure ONH tissue blood flow (MT) and its change (MT-change).
- Multivariable linear mixed-effects modeling to correlate ONH vasoreactivity with visual field total deviation (TD) slope over at least 2 years.
Main Results:
- Lower baseline ONH tissue blood flow (MT) and higher diastolic blood pressure were associated with reduced vasoreactivity (MT-change).
- Vasoreactivity (MT-change) significantly predicted the rate of visual field defect progression (TD slope).
Conclusions:
- Weaker ONH vasoreactivity to hyperoxia, assessed by laser speckle flowgraphy, correlates with lower baseline blood flow, higher diastolic blood pressure, and faster visual field loss.
- Laser speckle flowgraphy during oxygen testing shows promise as a predictive biomarker for glaucoma progression.
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