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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Published on: March 20, 2020

Triple-Negative Lobular Breast Cancer Causing Hydronephrosis.

Michael Chahin¹, Hardik Chhatrala¹, Nithya Krishnan¹

¹University of Florida, Jacksonville, FL, USA.

Journal of Investigative Medicine High Impact Case Reports

|February 12, 2020

Summary

Triple-negative breast cancer (TNBC) can metastasize to unusual sites like the ureter, causing hydronephrosis. Prompt intervention and treatment, such as ureteral stenting and paclitaxel, are crucial for managing this aggressive cancer.

Keywords:

breast cancer hydronephrosis negative receptor triple

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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

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Published on: January 12, 2017

Area of Science:

Oncology
Urology

Background:

Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited targeted therapy options.
Metastasis commonly occurs in bone, liver, lung, and brain, leading to poor prognosis.
Ureteral involvement by breast cancer is rare, posing diagnostic and management challenges.

Observation:

A patient with known TNBC presented with nausea, vomiting, and hydronephrosis.
Computed tomography revealed a pelvic mass obstructing the ureter.
Biopsy confirmed the mass as TNBC metastasis to the ureter.

Findings:

The patient underwent ureteral stent placement to relieve obstruction and preserve renal function.
She showed a positive response to paclitaxel chemotherapy.
This case highlights an unusual site of TNBC metastasis.

Implications:

Hydronephrosis from malignancy necessitates prompt management to prevent irreversible renal damage.
Early diagnosis and multimodal treatment are vital for improving outcomes in patients with metastatic TNBC.
This case underscores the importance of considering rare metastatic sites in breast cancer patients with unexplained symptoms.