Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

900
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
900
Depth Perception and Spatial Vision01:15

Depth Perception and Spatial Vision

1.7K
Depth perception is the ability to perceive objects three-dimensionally. It relies on two types of cues: binocular and monocular. Binocular cues depend on the combination of images from both eyes and how the eyes work together. Since the eyes are in slightly different positions, each eye captures a slightly different image. This disparity between images, known as binocular disparity, helps the brain interpret depth. When the brain compares these images, it determines the distance to an object.
1.7K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

5.0K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
5.0K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

9.2K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
9.2K
Glaucoma: Overview01:25

Glaucoma: Overview

1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-nuclei UPR profiling by flow cytometry reveals bortezomib resistance mechanisms in multiple myeloma.

EMBO molecular medicine·2026
Same author

Individual differences reveal distinct age-related reorganizations in spatial channels for luminance and texture processing.

npj aging·2026
Same author

Primary congenital glaucoma in a patient with Coffin-siris syndrome type 1 due to an ARID1B mutation: a novel association.

Ophthalmic genetics·2026
Same author

A novel case of Heimler syndrome in a young child with compound heterozygous PEX26 mutations: clinical and genetic insights with literature review.

Ophthalmic genetics·2026
Same author

Frequency tagged multifocal pupillary response fields identify age-related macular degeneration and diabetic retinopathy.

Frontiers in neuroscience·2026
Same author

Anterior megalophthalmos associated with CPAMD8 mutation: a case report.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2026
Same journal

Computational and mathematical models in vision: Quantitative approaches to understanding visual perception.

Vision research·2026
Same journal

Complex interactions between lightness, chroma, and hue in color ensemble perception.

Vision research·2026
Same journal

Driving with autism spectrum disorder: Exploring the impact of tactile hazard warnings on gaze behavior and hazard responses.

Vision research·2026
Same journal

Early visual processing in adults with ADHD: evidence from contrast sensitivity, spatial integration, and external noise.

Vision research·2026
Same journal

Pupil reflexes generate the peripheral drift illusion due to ON/OFF motion responses.

Vision research·2026
Same journal

Perceived direction of glass patterns can flip by 90°: A neural model.

Vision research·2026
See all related articles

Related Experiment Video

Updated: Dec 28, 2025

The Measurement and Treatment of Suppression in Amblyopia
08:34

The Measurement and Treatment of Suppression in Amblyopia

Published on: December 14, 2012

50.5K

Interocular suppressive interactions in amblyopia depend on spatial frequency.

Marie Beylerian1, Robert F Hess2, Frédéric Matonti3

  • 1Department of Ophthalmology, CHU NORD, Marseille, France; Institut de Neurosciences de la Timone (INT), Centre National de la Recherche Scientifique (CNRS) and Aix-Marseille Université (AMU), Marseille, France.

Vision Research
|February 12, 2020
PubMed
Summary
This summary is machine-generated.

Amblyopia involves vision imbalance where one eye dominates. This study reveals that suppressive interactions in amblyopia are spatial frequency-tuned, with weaker masking from the amblyopic eye.

Keywords:
AmblyopiaContrast sensitivityDichoptic maskingSpatial frequencyqCSF

More Related Videos

Stereoacuity Improvement using Random-Dot Video Games
06:25

Stereoacuity Improvement using Random-Dot Video Games

Published on: January 14, 2020

14.9K
Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia
06:19

Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia

Published on: September 27, 2024

470

Related Experiment Videos

Last Updated: Dec 28, 2025

The Measurement and Treatment of Suppression in Amblyopia
08:34

The Measurement and Treatment of Suppression in Amblyopia

Published on: December 14, 2012

50.5K
Stereoacuity Improvement using Random-Dot Video Games
06:25

Stereoacuity Improvement using Random-Dot Video Games

Published on: January 14, 2020

14.9K
Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia
06:19

Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia

Published on: September 27, 2024

470

Area of Science:

  • Vision science
  • Neuroscience
  • Ophthalmology

Background:

  • Amblyopia, or "lazy eye," involves reduced vision in one eye, often due to an interocular suppressive imbalance.
  • The fixing eye typically dominates perception in amblyopia, but the nature of this suppressive interaction (spatial frequency-tuned or not) is unclear.

Purpose of the Study:

  • To investigate whether interocular suppressive interactions in amblyopia are tuned for spatial frequency.
  • To compare the strength and spatial frequency tuning of dichoptic masking between amblyopic and control subjects.

Main Methods:

  • Utilized the quick Contrast Sensitivity Function (qCSF) approach to measure contrast sensitivity and masking functions.
  • Assessed monocular sensitivity, followed by dichoptic masking measurements using low, mid, and high spatial frequency masks in 15 amblyopic and 17 control participants.
  • Normalized masking functions to each participant's visibility threshold.

Main Results:

  • In controls, dichoptic masking was equivalent between eyes and tuned for spatial frequency (e.g., low spatial frequencies primarily masked low spatial frequencies).
  • In amblyopes, interocular masking was also spatial frequency-tuned but asymmetric: masking from the amblyopic to the fixing eye was weaker than vice versa.
  • This asymmetry was not due to the amblyopic eye's contrast sensitivity deficit or strong masking from the fixing eye, but rather weak masking originating from the amblyopic eye.

Conclusions:

  • Interocular suppressive interactions in amblyopia are tuned for spatial frequency, similar to controls.
  • A key finding is the asymmetric masking strength between the eyes in amblyopia, primarily due to reduced masking originating from the amblyopic eye.
  • This suggests a specific deficit in the processing or transmission of suppressive signals from the amblyopic eye.