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Related Experiment Video

Updated: Dec 28, 2025

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Published on: November 18, 2016

From Shape to Function: The Next Step in Bioprinting.

Riccardo Levato^1,2, Tomasz Jungst³, Ruben G Scheuring³

¹Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, 3584 CX, Utrecht, The Netherlands.

Advanced Materials (Deerfield Beach, Fla.)

|February 12, 2020

Summary

This summary is machine-generated.

The biofabrication field now has advanced materials and printing techniques. The focus must shift from technology to achieving biological function in engineered tissues.

Keywords:

biofabrication bioinks biological function regenerative medicine tissue hierarchy

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Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

The "biofabrication window" highlighted challenges in biofabrication and bioprinting due to limited printable bioinks and printing methods.
Recent advancements have introduced numerous bioinks and improved printing technologies.

Purpose of the Study:

To summarize material and technological progress in biofabrication since 2013.
To shift the focus towards achieving biological function in engineered constructs.
To outline a vision for developing biological function from shape determination.

Main Methods:

Review of recent material and technological advancements in biofabrication.
Discussion on strategies for acquiring biological function in cell-material constructs.
Conceptual framework for evolving biological function from controlled shape.

Main Results:

A wide array of bioinks and advanced printing techniques are now available.
Key knowledge gaps remain regarding essential parameters for fabricating hierarchical, functional tissue constructs.
A paradigm shift is needed from material/technology focus to biological development.

Conclusions:

While biofabrication technology has advanced, achieving true biological function in engineered tissues remains a challenge.
Future research should prioritize understanding and guiding the biological development of constructs.
The ability to control shape offers a pathway to engineer biological function.