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Related Experiment Video

Updated: Dec 28, 2025

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device
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Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices.

Lingling Kong1,2, Aviad Levin2, Zenon Toprakcioglu2

  • 1State Key Laboratory of Bioreactor Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.

Langmuir : the ACS Journal of Surfaces and Colloids
|February 12, 2020
PubMed
Summary

This study introduces a novel microfluidic device for creating uniform water/oil/water double emulsions. The design simplifies surface treatment, enabling controlled emulsion formation without complex lithography.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Fluid Dynamics

Background:

  • Microemulsions offer diverse applications due to their unique properties.
  • Microfluidics enables controlled production of monodisperse emulsions, including complex hierarchical types.
  • Conventional poly(dimethylsiloxane) microfluidic systems face challenges in precise surface chemistry control for double emulsion generation at the micrometer scale.

Purpose of the Study:

  • To present a novel two-dimensional microfluidic device for straightforward fabrication of uniform water/oil/water double emulsions.
  • To demonstrate a simplified surface treatment approach for microfluidic devices.
  • To overcome the limitations of spatial control in conventional microfluidic systems for double emulsion generation.

Main Methods:

  • A two-dimensional microfluidic device design with selectively treatable surfaces was developed.
  • Distinct hydrophilic and hydrophobic surface properties were combined within the device.
  • Simple pressure-driven flows and lipid molecules as surfactants were utilized for emulsion generation.

Main Results:

  • The device allows for selective surface treatment without lithography or complex flow control.
  • Uniform water/oil/water double emulsions were successfully formed.
  • A mismatch in wettability between the continuous phase and channel wall was tolerated over hundreds of micrometers.
  • The approach demonstrated robust efficiency in emulsion generation and simple device fabrication.

Conclusions:

  • The presented microfluidic device offers a simplified and effective method for producing uniform water/oil/water double emulsions.
  • This design overcomes challenges in surface chemistry control for microfluidic emulsion generation.
  • The approach holds potential for various applications, including those utilizing lipid-based surfactants.