Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.5K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.8K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
T Cell Types and Functions01:24

T Cell Types and Functions

2.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.0K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.7K
Hematopoiesis01:21

Hematopoiesis

8.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.7K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

Nature immunology·2026
Same author

Defining the rules of engagement: B cells, antibodies and cancer control.

Cellular & molecular immunology·2026
Same author

Interleukin 4 selectively expands functional type 1 conventional dendritic cells from bone marrow progenitors.

Cell reports·2025
Same author

Technological advances in the search for a CURE for asthma.

The Medical journal of Australia·2025
Same author

Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen-presenting cell network.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.

Nature immunology·2025

Related Experiment Video

Updated: Dec 28, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K

EZH2 function in immune cell development.

Stephen L Nutt1,2, Christine Keenan1,2, Michaël Chopin1,2

  • 1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

Biological Chemistry
|February 12, 2020
PubMed
Summary
This summary is machine-generated.

Polycomb repressive complex 2 (PRC2), particularly EZH2, is crucial for immune cell development and function. EZH2 inhibition shows promise for treating cancers and autoimmune diseases by modulating immune responses.

Keywords:
gene silencinghistone methyltransferaseimmunitylymphocyte differentiationpolycomb repressive complex 2

More Related Videos

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

3.8K
Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
05:03

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

1.1K

Related Experiment Videos

Last Updated: Dec 28, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K
Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

3.8K
Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
05:03

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

1.1K

Area of Science:

  • Epigenetics and Immunology
  • Molecular Biology

Background:

  • Polycomb repressive complex 2 (PRC2) is an epigenetic regulator with key components EZH2, SUZ12, and EED.
  • EZH2 catalyzes histone H3 lysine 27 methylation, a mark associated with gene silencing.
  • EZH1 is a partially redundant methyltransferase found in higher vertebrates.

Purpose of the Study:

  • To review the established roles of EZH2 and PRC2 in immune system development and function.
  • To explore the therapeutic potential of EZH2 inhibitors in cancer and autoimmune diseases.

Main Methods:

  • Literature review of studies on EZH2 and PRC2 in the immune system.
  • Analysis of EZH2's function in hematopoietic stem cells, lymphocyte development, and adaptive immunity.
  • Examination of EZH2's involvement in immune homeostasis and inflammatory conditions.

Main Results:

  • EZH2 is essential for hematopoietic stem cell function and lymphocyte development, partly by repressing cell cycle inhibitors.
  • EZH2 plays critical roles in humoral and cell-mediated adaptive immunity and immune homeostasis.
  • Overactive EZH2 in cancers has led to the development of EZH2 inhibitors.
  • EZH2 inhibition demonstrates potential in dampening immune responses for inflammatory and autoimmune settings.

Conclusions:

  • EZH2 and PRC2 are vital regulators of immune cell development and function.
  • Targeting EZH2 offers a promising therapeutic strategy for various immune-related disorders and cancers.