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The Epigenetics of the Endocannabinoid System
Rosaria Meccariello1, Antonietta Santoro2, Stefania D'Angelo1
1Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, Italy.
International Journal of Molecular Sciences
|February 13, 2020
Summary
The endocannabinoid system (ES) is epigenetically modulated by lifestyle and environmental factors. This review explores the epigenetics of the ES, focusing on its role in reproduction and fertility.
Area of Science:
- Endocrinology
- Epigenetics
- Reproductive Biology
Background:
- The endocannabinoid system (ES) is a crucial cell-signalling network involved in various physiological processes.
- Dysregulation of the ES is linked to disorders including infertility, metabolic, neurological, and behavioral conditions.
- Epigenetic modifications, which alter gene expression without changing DNA sequence, are increasingly recognized as key regulators of health and disease.
Purpose of the Study:
- To provide an updated review on the epigenetics of the endocannabinoid system.
- To highlight the emerging role of ES epigenetics in reproductive health and fertility.
- To discuss how lifestyle and environmental factors influence ES epigenetic regulation.
Main Methods:
- Literature review of recent findings on endocannabinoid system epigenetics.
- Analysis of studies investigating epigenetic modulation by cannabinoids and related compounds.
- Examination of evidence for trans-generational epigenetic inheritance via the ES.
Main Results:
- The ES is subject to epigenetic modulation by endogenous and exogenous factors.
- Cannabinoids and related compounds can induce widespread or gene-specific epigenetic changes.
- Evidence suggests the potential for trans-generational epigenetic inheritance of ES-related epigenetic marks through gametes.
Conclusions:
- Epigenetic mechanisms play a significant role in regulating the endocannabinoid system.
- Understanding ES epigenetics is crucial for addressing fertility issues and reproductive health.
- Further research into the trans-generational effects of ES epigenetic modifications is warranted.
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