Shared Molecular Features Linking Endometriosis and Obstetric Complications
Hiroshi Kobayashi1, Naoki Kawahara2, Kenji Ogawa2
1Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, 634-8522, Japan. hirokoba@naramed-u.ac.jp.
Reproductive Sciences (Thousand Oaks, Calif.)
|February 13, 2020
Summary
Endometriosis increases the risk of adverse pregnancy outcomes. Epigenetic changes, common in endometriosis, may also link it to complications like preeclampsia and preterm birth.
Area of Science:
- Reproductive Medicine
- Genetics
- Obstetrics
Background:
- Epidemiological studies indicate a higher risk of adverse pregnancy outcomes in women with endometriosis.
- Endometriosis development is linked to epigenetic alterations in endometrial cells.
Purpose of the Study:
- To investigate shared pathophysiological mechanisms between endometriosis and obstetric complications.
- To explore the role of epigenetic changes in linking these conditions.
Main Methods:
- A systematic literature review was conducted.
- Studies published between January 2008 and October 2018 were analyzed.
- Focus was on epigenetic alterations in endometriosis and obstetric complications.
Main Results:
- Epigenetic dysregulation is implicated in endometriosis development.
- Common epigenetic alterations are observed in endometriosis, preeclampsia, small for gestational age (SGA), and preterm birth.
- Specific genes (DLX5, GATA3, CDKN1C, PTGER2) show aberrant expression or methylation patterns.
Conclusions:
- Epigenetic changes may represent a shared mechanism linking endometriosis with obstetric complications like preeclampsia, SGA, and preterm birth.
- Further research is needed to establish epigenetic links with other complications such as postpartum hemorrhage or placental abruption.
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