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Updated: Dec 28, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Do Antibiotic-Impregnated Intramedullary Dowels Assist in Eradicating Infection in Total Knee Arthroplasty? Pro
Brandon H Naylor1, Giles R Scuderi1
1Department of Orthopedic Surgery, Lenox Hill Hospital, New York, NY.
Abstract:
Antibiotic-loaded bone cement (ALBC) spacer constructs for the treatment of periprosthetic joint infections of the knee continue to evolve from the original hockey puck designs. Countless techniques have since been described for augmentation of ALBC spacers with the use of intramedullary (IM) dowels. The use of IM dowels has become a vital addition to any knee spacer construct. ALBC IM dowels are an excellent vessel to provide targeted local antibiotic treatment to high-risk areas like the medullary canal while increasing the overall therapeutic antibiotic elution. In addition, IM dowels provide needed stabilization to the relatively unstable intra-articular spacer component, thereby reducing spacer-related complications like displacement and fracture. Therefore, we recommend regular use of IM dowel augmentation to ALBC spacer constructs.
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