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[Immunotherapy and radiotherapy for management of breast cancer: Rational and overview on clinical practice]

L M Abbassi1, K I Cao1, Y M Kirova1

  • 1Département d'oncologie radiothérapie, Institut Curie, 26, rue d'Ulm, 75005 Paris, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|February 13, 2020
PubMed

The discovery of immunotherapy led to understand the major role of immune system during the tumor process. Conventional treatments, such as chemotherapy, are directly tumoricidal. New drugs are developed to target specifically the immune system to make it regain its ability to recognize and eliminate cancer cells. Radiotherapy is used for a long time for its local action, but its systemic role, based on its impact on immunity, is now better known. Breast cancer was wrongly considered poorly immunogenic and put aside the amazing progress in this new area of treatment. In this article, we would like to present the pre-clinical and clinical rationales to associate immunotherapy to radiotherapy in the management of breast cancer.

Keywords:
Breast cancerCancer du seinImmunotherapyImmunothérapieRadiotherapyRadiothérapie

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