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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Brain Structural and Functional Imaging Findings in Medication-Overuse Headache.

Catherine D Chong¹

¹Mayo Clinic, Phoenix, AZ, United States.

Frontiers in Neurology

|February 13, 2020

Summary

Medication-overuse headache (MOH) is linked to brain changes. Neuroimaging shows structural and functional brain alterations, but recovery is possible after stopping overuse medication.

Keywords:

medication-overuse headache migraine pathophysiology resting-state connectivity structural and functional neuroimaging

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Area of Science:

Neuroscience
Neurology
Radiology

Background:

Medication-overuse headache (MOH) is a common and disabling headache disorder.
Understanding the underlying neurobiological mechanisms of MOH is crucial for effective treatment.

Purpose of the Study:

To review neuroimaging findings in patients with medication-overuse headache.
To explore the relationship between medication overuse, brain changes, and recovery.

Main Methods:

Narrative review of research neuroimaging studies in MOH patients.
Analysis of findings related to brain structure, function, and neuropathology.

Main Results:

Correlations identified between neuropathology and medication overuse.
Observed changes in brain morphology and cortical function in MOH patients.
Evidence of brain recovery following cessation of overused medication.

Conclusions:

MOH involves exacerbated brain structural and functional changes in pain and reward circuits.
Brain modifications in MOH suggest both state-dependent (modification) and trait-like (adaptation/recovery) neuromechanisms.
Medication withdrawal is associated with brain recovery, highlighting its therapeutic potential.