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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
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Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside
Jinghua Wang1,2, Shushan Yan3, Jinghan Yang1,2
1Clinical Medicine College, Weifang Medical University, Weifang, China.
Frontiers in Immunology
|February 13, 2020
Summary
This review explores how non-coding RNAs (ncRNAs) contribute to rheumatoid arthritis (RA) pathogenesis. Identifying these ncRNAs may lead to new diagnostic biomarkers for RA.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Rheumatoid arthritis (RA) is a systemic autoimmune disease causing joint inflammation and destruction.
- Synovitis and vasculitis are key pathological features of RA.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in immune regulation.
Purpose of the Study:
- To review the role of ncRNAs in rheumatoid arthritis pathogenesis.
- To highlight ncRNAs as potential diagnostic and therapeutic biomarkers for RA.
Main Methods:
- Literature review of studies on ncRNAs and RA.
- Analysis of the regulatory functions of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in RA.
Main Results:
- ncRNAs, including miRNAs, lncRNAs, and circRNAs, are critical regulators in RA.
- Specific ncRNAs have been identified as promising biomarkers for RA diagnosis and treatment.
- Understanding ncRNA regulation offers insights into RA pathophysiology.
Conclusions:
- ncRNAs play a significant role in the development and progression of rheumatoid arthritis.
- Targeting ncRNAs presents a potential strategy for RA diagnosis and therapy.
- Further research into ncRNA biomarkers is crucial for advancing RA management.
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