Related Experiment Video

Updated: Dec 28, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.9K

Systematically Dissecting the Function of RNA-Binding Proteins During Glioma Progression

Jianjun Wang1, Jianfeng Qi1,2, Xianzeng Hou1

  • 1Department of Neurosurgery, The First Hospital Affiliated with Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, China.

Frontiers in Genetics
|February 13, 2020
PubMed

Insights

This study analyzed RNA-binding proteins (RBPs) in glioma, identifying key mutated and expressed RBPs. Findings reveal RBP roles in glioma progression and potential therapeutic targets for patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • RNA-binding proteins (RBPs) are crucial for gene expression regulation.
  • Dysregulation of RBPs is implicated in various cancers, but their role in glioma progression, especially in Chinese patients, remains underexplored.

Purpose of the Study:

  • To systematically analyze the somatic mutation and gene expression patterns of 2949 RBPs during glioma progression.
  • To identify key RBPs involved in glioma development and their prognostic significance.
  • To provide a valuable resource for developing therapeutic targets for glioma.

Main Methods:

  • Comprehensive analysis of somatic mutations and gene expression data for 2949 RBPs in glioma.
  • Construction of a regulatory network integrating RBP expression and gene interactions.
  • Identification of RBPs significantly associated with patient overall survival.

Main Results:

  • Identified highly mutated genes (e.g., ATRX, TTN, SETD2) and differentially expressed genes (e.g., KIF4A, TTK, CEP55) among RBPs in glioma.
  • Established functional links between RBPs and cancer-related genes through a regulatory network.
  • Revealed a prognosis spectrum for RBPs, with genes like SNRPN and IGF2BP3 significantly correlating with overall survival across all glioma grades.

Conclusions:

  • This study offers a valuable resource on RBPs in glioma progression.
  • Identified specific RBPs as potential therapeutic targets for glioma treatment.
  • Highlights the prognostic value of certain RBPs in glioma patients.
Keywords:
RNA-binding proteinglioma progressionmutationsprognosisregulatory network

More Related Videos

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.2K
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

10.0K

Related Concept Videos

Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
5.1K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.3K
Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
9.4K