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MicroRNA-183 in Cancer Progression
Dingren Cao1, Min Di2, Jingjie Liang1
1College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
Journal of Cancer
|February 13, 2020
Summary
MicroRNA-183 (miR-183) shows varied expression in tumors, acting as both an oncogene and antioncogene. This review explores its regulatory pathways and roles in cancer progression, offering insights into its therapeutic potential.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- MicroRNA-183 (miR-183) is frequently dysregulated in various cancers, influencing tumor initiation and progression.
- Its expression patterns are complex, with reports of upregulation, downregulation, or both in different cancer types.
- miR-183 can function as an oncogene or antioncogene, directly or indirectly modulating cancer-related genes.
Purpose of the Study:
- To review the regulators of miR-183 expression.
- To summarize the expression profile of miR-183 across diverse cancers.
- To elucidate the functional roles of miR-183 and its target genes in cancer, focusing on cell migration, invasion, epithelial-mesenchymal transition (EMT), and angiogenesis.
Main Methods:
- Literature review of studies on miR-183 expression and function in cancer.
- Analysis of reported miR-183 target genes and their associated pathways.
- Focus on key cancer processes: cell migration, invasion, EMT, and microangiogenesis.
Main Results:
- miR-183 expression is context-dependent, being upregulated in 18 cancers, downregulated in 6, and showing mixed reports in 7 others.
- miR-183 directly impacts cancer development by acting as an oncogene or antioncogene.
- Key roles identified in promoting cell migration, invasion, EMT, and microangiogenesis.
Conclusions:
- The diverse roles of miR-183 in cancer stem from its complex regulatory network and context-specific functions.
- miR-183 and its downstream effectors represent potential prognostic biomarkers and therapeutic targets for various cancers.
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