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Updated: Dec 28, 2025
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Androgen Deprivation Therapy and Cognitive Function in Prostate Cancer
Jonathan Kluger1, Alicia Roy2, Herta H Chao3
1Yale University School of Medicine, 367 Cedar Street, New Haven, CT, 06510, USA.
Current Oncology Reports
|February 13, 2020
Summary
Androgen deprivation therapy (ADT) for prostate cancer may affect cognitive function, but current evidence is inconsistent. Further research with improved methods is needed to understand ADT
Area of Science:
- Neuroscience
- Oncology
- Gerontology
Background:
- Androgen deprivation therapy (ADT) is a standard treatment for prostate cancer.
- Growing interest exists in understanding the potential impact of ADT on cognitive function.
- Existing research on ADT and cognition yields conflicting results.
Purpose of the Study:
- To review the current understanding of how androgen deprivation therapy affects cognitive function in prostate cancer patients.
- To identify limitations in current assessment methods and suggest future research directions.
Main Methods:
- Review of existing animal and human studies on androgens and cognition.
- Analysis of findings from neurocognitive tests and large electronic patient databases.
- Examination of limited functional imaging data related to ADT and brain changes.
Main Results:
- Studies have not consistently shown ADT-induced cognitive impairment using standard neurocognitive tests.
- Retrospective analyses of large databases provide conflicting results regarding ADT and dementia risk.
- Limited data exists on ADT-induced brain changes via functional imaging.
Conclusions:
- It remains unclear if ADT causes cognitive deficits in patients.
- Current neurocognitive tests may not detect subtle cognitive impairments.
- Improved prospective assessment tools are necessary to evaluate the cognitive impact of ADT.
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