Related Experiment Video
Updated: Dec 28, 2025
12:16
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
15.4K
Cellular Immunotherapy in Lymphoma: Beyond CART Cells
Mahmoud R Gaballa1, Carlos A Ramos2
1Hematology-Oncology Section, Department of Medicine, Baylor College of Medicine, 6565 Fannin A6-080, Houston, TX, 77019, USA.
Current Treatment Options in Oncology
|February 13, 2020
Summary
Cellular immunotherapies like CAR T-cells show promise for lymphoma but have limitations. Newer T cell receptor (TCR) therapies and off-the-shelf NK/NKT cell products offer expanded options for relapsed and refractory lymphoma.
Area of Science:
- Oncology
- Immunology
- Cellular Therapy
Background:
- Cellular immunotherapy is advancing for relapsed/refractory lymphoma.
- CD19-specific chimeric antigen receptor T cells (CARTs) demonstrate significant clinical success.
- Existing CART therapies have limitations, such as targeting only cell surface antigens.
Purpose of the Study:
- To explore limitations of current CART therapies.
- To discuss alternative cellular immunotherapy approaches for lymphoma.
- To highlight the potential of novel platforms for improved patient outcomes.
Main Methods:
- Review of current literature on cellular immunotherapies for lymphoma.
- Comparison of CART and T cell receptor (TCR) T cell functionalities.
- Discussion of emerging platforms like NK and NKT cells.
Main Results:
- CARTs are limited to cell surface antigens, unlike TCRs which can target intracellular proteins.
- TCR-engineered T cells targeting nonviral tumor antigens are experimental but promising.
- Allogeneic, "off-the-shelf" cellular products (e.g., NK/NKT cells) could overcome manufacturing delays.
Conclusions:
- While CARTs are effective, their limitations necessitate exploration of alternative strategies.
- TCR-based therapies and novel cellular platforms offer potential advancements in lymphoma treatment.
- The evolving landscape of cellular therapy is expanding options for patients with relapsed and refractory lymphoma.
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