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Related Concept Videos

Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Developmental variability channels mouse molar evolution.

Luke Hayden1,2, Katerina Lochovska3, Marie Sémon1

  • 1Laboratoire de Biologie et Modélisation de la Cellule, Université de Lyon, CNRS UMR 5239, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon1, INSERM U1210, Lyon, France.

Elife
|February 13, 2020
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Summary
This summary is machine-generated.

Murine molar development shows a preferred direction of anterior elongation. This study reveals how developmental system instabilities drive evolutionary changes in tooth morphology.

Keywords:
developmental biologydevelopmental constraintevo-devoevolutionary biologyline of least resistancemolarmouserodent

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Area of Science:

  • Evolutionary developmental biology
  • Developmental plasticity
  • Morphological evolution

Background:

  • Developmental systems can influence evolutionary trajectories by producing specific types of variation.
  • The murine first upper molar exhibits a recurring pattern of anterior elongation across different evolutionary scales.
  • Understanding the developmental basis of this variation is key to explaining evolutionary trends.

Purpose of the Study:

  • To investigate whether developmental systems bias phenotypic evolution towards specific directions.
  • To identify the developmental mechanisms underlying the anterior elongation of the murine first upper molar.
  • To explore the role of signaling center activity and its regulation in tooth development and evolution.

Main Methods:

  • Utilized a novel quantitative approach to compare molar development in two mouse strains with distinct molar lengths.
  • Analyzed temporal, spatial, and functional differences in tooth signaling center activity.
  • Traced the developmental fate of signaling centers to understand their contribution to molar morphology.

Main Results:

  • Identified differential tuning of activation-inhibition mechanisms in tooth signaling centers between mouse strains.
  • Explained the specific anterior elongation of the upper first molar through developmental pathways.
  • Observed significant variation in tooth length and developmental timing even without genetic variation, indicating system instability.

Conclusions:

  • Murine molar development exhibits inherent variational properties that channel evolution along predictable paths.
  • The developmental system's intrinsic instability contributes to morphological evolution.
  • Developmental systems possess a 'line of least resistance' that guides evolutionary change.