Related Experiment Video

Updated: Dec 28, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.1K

Use of Lipids in Neonates Requiring Parenteral Nutrition

Girish C Deshpande1,2, Wei Cai3

  • 1Neonatal NICU, Nepean Hospital, Kingswood, NSW, Australia.

JPEN. Journal of Parenteral and Enteral Nutrition
|February 13, 2020
PubMed

Insights

For neonates needing parenteral nutrition, fish-oil-based lipid emulsions are superior. They reduce oxidative stress and inflammation while boosting essential fatty acids, unlike soybean or olive oil emulsions.

Area of Science:

  • Neonatal nutrition
  • Biochemistry
  • Clinical trials

Background:

  • Neonates, especially preterm infants, have low antioxidant capacity, increasing susceptibility to oxidative stress, inflammation, and related conditions like bronchopulmonary dysplasia.
  • Parenteral nutrition in neonates requires specific nutrients, including conditionally essential very long-chain omega-3 polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), vital for development and with anti-inflammatory properties.

Purpose of the Study:

  • To evaluate the impact of different lipid emulsions on oxidative stress, inflammation, and fatty acid levels in neonates receiving parenteral nutrition.
  • To compare the efficacy of composite fish-oil-containing lipid emulsions against soybean oil and olive oil-based emulsions.

Main Methods:

  • Review of clinical trials involving preterm and term neonates receiving parenteral nutrition.
  • Emphasis on analyzing markers of oxidative stress, lipid peroxidation, and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels.

Main Results:

  • Soybean oil-based lipid emulsions may exacerbate lipid peroxidation, oxidative stress, and inflammation due to high omega-6 and low omega-3 PUFA content.
  • Olive oil/soybean oil emulsions showed limited benefits in neonatal populations.
  • Composite fish-oil-containing lipid emulsions demonstrated a reduction in oxidative stress and lipid peroxidation.
  • These fish-oil-based emulsions also led to increased levels of DHA and EPA in neonates.

Conclusions:

  • Composite fish-oil-containing lipid emulsions offer significant advantages over soybean oil or soybean/olive oil-based emulsions for neonates requiring parenteral nutrition.
  • The improved oxidative stress profile and enhanced DHA/EPA levels suggest potential clinical benefits for neonatal outcomes.

Keywords:
fish oilinflammationlipidsneonate: oxidative stressomega-3omega-6parenteral nutritionpediatricsoybean oil

More Related Videos

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs06:25

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

9.9K
Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro08:53

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

Published on: January 11, 2017

9.3K

Related Concept Videos

Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
619
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.8K
Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
98.3K
Lipids as Anchors01:32

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
7.0K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
204
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.3K