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Updated: Dec 28, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Theoretical Study on Deep Eutectic Solvents as Vehicles for the Delivery of Anesthetics
Alberto Gutiérrez1, Mert Atilhan2,3, Santiago Aparicio1
1Department of Chemistry, University of Burgos, 09001 Burgos, Spain.
Abstract:
The solvation and solubilization of selected anesthetic active pharmaceutical ingredients (bupivacaine, prilocaine, and procaine) in arginine-based deep eutectic solvents are studied using a theoretical approach considering quantum chemistry and classical molecular dynamics. The intermolecular forces between the anesthetics and the solvent are characterized, with particular attention to hydrogen bonding, in terms of strength, topological properties, interaction mechanism, structuring, and dynamic properties of solvation shells. The reported results show the nanoscopic properties that confirm these solvents as suitable materials for anesthetics drug delivery in the liquid phase.
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