Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

439
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
439
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.5K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

822
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
822
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

762
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
762
Immunological Memory01:23

Immunological Memory

14.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic potential for IgM antibody detection by the DPP Syphilis TnT assay in neonates at risk for congenital syphilis.

Journal of clinical microbiology·2026
Same author

Proteome microarray-guided identification of mycobacterial antigens and ELISA-based peptide mapping for improved serological detection of <i>Mycobacterium bovis</i> infection in European badgers.

Journal of clinical microbiology·2026
Same author

Diagnostic Potential for IgM Antibody Detection by the DPP Syphilis TnT Assay in Neonates at Risk for Congenital Syphilis.

medRxiv : the preprint server for health sciences·2026
Same author

Optimization of a molecularly defined tuberculin formulation: recombinant fusion proteins and epitope surgery.

Journal of clinical microbiology·2025
Same author

Rapid detection of systemic and mucosal antibody responses to COVID-19 infection or vaccination.

International immunopharmacology·2025
Same author

Comparative performance of tuberculin and defined-antigen cocktails for detecting bovine tuberculosis in BCG-vaccinated cattle in natural settings.

Scientific reports·2025
Same journal

Early in vitro response to Toxoplasma gondii infection in macrophages and neutrophils from sheep immunized with a commercial vaccine.

Veterinary immunology and immunopathology·2026
Same journal

Host immune response to lumpy skin disease virus.

Veterinary immunology and immunopathology·2026
Same journal

A randomized field trial of live epizootic bovine abortion agent (EBAA) vaccine demonstrates safety and efficacy.

Veterinary immunology and immunopathology·2026
Same journal

Comparative evaluation of lateral flow immunoassay and real time PCR for detection of canine morbillivirus antigen in live attenuated vaccines.

Veterinary immunology and immunopathology·2026
Same journal

Establishment of a disease model for Mycoplasma Ovipneumoniae infectioninfection in Hu sheep and its lung transcriptomic analysis.

Veterinary immunology and immunopathology·2026
Same journal

Macrophage-mediated inflammatory responses impair mucosal barrier components and promote goblet cell loss during Eimeria tenella infection in chickens.

Veterinary immunology and immunopathology·2026
See all related articles

Related Experiment Video

Updated: Dec 28, 2025

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.6K

Memory B cells and tuberculosis.

Konstantin P Lyashchenko1, H Martin Vordermeier2, W Ray Waters3

  • 1Chembio Diagnostics Systems, Inc., Medford, NY, USA.

Veterinary Immunology and Immunopathology
|February 13, 2020
PubMed
Summary
This summary is machine-generated.

Immunological memory involves diverse memory B cell subsets in tuberculosis. Some atypical memory B cells impair host immunity, while others aid in immune responses and diagnostics.

Keywords:
Antibody responseB cellsImmunological memoryMycobacterium bovisMycobacterium tuberculosisTuberculosis

More Related Videos

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.4K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.8K

Related Experiment Videos

Last Updated: Dec 28, 2025

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.6K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.4K
Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.8K

Area of Science:

  • Immunology
  • Microbiology

Background:

  • Immunological memory is crucial for adaptive immunity.
  • Memory B cells are generated through antigen stimulation and can exhibit heterogeneity.
  • Tuberculosis (TB) infection involves distinct memory B cell subsets, including atypical ones.

Purpose of the Study:

  • To review recent advances in memory B cell generation, re-activation, heterogeneity, and function in tuberculosis.
  • To discuss the role of memory B cells in bovine tuberculosis and their diagnostic implications.

Main Methods:

  • Review of existing human and animal studies on memory B cells in tuberculosis.
  • Analysis of B cell populations, including IgD+ CD27+, IgM+ CD27+, and atypical memory B cells.
  • Examination of B cell recruitment to infection sites and granulomas.

Main Results:

  • Memory B cell populations in TB are heterogeneous, with functionally distinct subsets.
  • Atypical memory B cells lacking CD27 expression are expanded in human TB and may impair immunity.
  • B cells are recruited to TB infection sites and form germinal center-like structures.
  • Cattle infected with M. bovis develop IgM+, IgG+, and IgA+ memory B cells that rapidly differentiate upon re-exposure.

Conclusions:

  • Memory B cell heterogeneity plays a significant role in tuberculosis immunity.
  • Understanding memory B cell subsets is vital for developing effective TB diagnostics and therapies.
  • Further research into memory B cell functions can improve post-skin test recall antibody responses in bovine TB.