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Updated: Dec 28, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and

Sara B Salazar1, Rita S Simões1, Nuno A Pedro1

  • 1Department of Bioengineering, Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.

Journal of Fungi (Basel, Switzerland)
|February 14, 2020
PubMed

Insights

Emerging antifungal resistance in Candida infections necessitates new treatments. This review explores current antifungal drugs, resistance mechanisms, and novel therapies like natural compounds and probiotics to combat candidiasis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Fungal infections caused by Candida species are increasing, leading to significant mortality and morbidity.
  • Candidiasis ranges from superficial to life-threatening disseminated forms.
  • Emergence of antifungal resistance, especially in non-albicans Candida, threatens current treatment efficacy.

Purpose of the Study:

  • To review the mechanisms of action of existing antifungal drugs.
  • To highlight resistance mechanisms in clinical Candida isolates.
  • To explore novel therapeutic strategies against pathogenic Candida species.

Main Methods:

  • Literature review of antifungal mechanisms and resistance.
  • Analysis of emerging therapeutic approaches, including natural products and probiotics.
  • Synthesis of information on current and novel anti-Candida therapies.

Main Results:

  • Current antifungals face challenges due to widespread resistance.
  • Mechanisms of resistance in clinical isolates are diverse.
  • Novel approaches involving natural/synthetic chemicals and probiotics show promise.

Conclusions:

  • Novel therapies, alone or combined with traditional antifungals, may offer new solutions.
  • Further research into these novel approaches is crucial for developing effective anti-Candida treatments.
  • Addressing antifungal resistance is critical for managing Candida infections.
Keywords:
Candidaantifungal drugsantimicrobialscandidiasisnon-conventional therapeuticsphytotherapeutics and probioticsresistance to antifungals

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