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Targeted Cancer Therapies

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Related Experiment Video

Updated: Dec 28, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

Photodynamic Therapy in Primary Breast Cancer.

Shramana M Banerjee^1,2, Soha El-Sheikh^1,3, Anmol Malhotra^1,4

¹Breast Unit and Royal Free London NHS Foundation Trust, London NW3 2QG, UK.

Journal of Clinical Medicine

|February 14, 2020

Summary

Photodynamic therapy (PDT) shows promise for early breast cancer treatment. This study found PDT safe and effective, with visible treatment effects correlating with light dosage.

Keywords:

MRI breast cancer clinical study photodynamic therapy

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Area of Science:

Oncology
Medical Imaging
Photochemistry

Background:

Photodynamic therapy (PDT) utilizes a photosensitizer and light to induce localized cell death.
Primary breast cancer management often involves surgery, with a need for minimally invasive therapeutic options.

Purpose of the Study:

To evaluate the safety and efficacy of image-guided photodynamic therapy (PDT) for primary breast cancer.
To assess the correlation between MRI findings and histology post-PDT.
To determine the dose-response relationship of escalating light doses in PDT.

Main Methods:

A phase I/IIa dose escalation study involving 12 patients with invasive ductal breast cancer.
Administration of verteporfin followed by interstitial laser light delivery under ultrasound guidance.
Pre- and post-PDT MRI scans and histological examination of excised tissue.

Main Results:

PDT was well-tolerated with no reported adverse events.
PDT-induced necrosis was detected by MRI in 7 patients and histology in 8 patients.
Treatment effects increased with light dose, showing good correlation between MRI and histology.

Conclusions:

Image-guided PDT with verteporfin is a safe and potentially effective treatment for early breast cancer.
PDT demonstrates distinct histological features of necrosis, differentiating it from spontaneous necrosis.
Long-term follow-up showed no adverse effects, supporting PDT's role in breast cancer management.