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Published on: February 14, 2018
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[Evaluation of Micafungin Use in Children]
Edanur Yeşil1, Solmaz Çelebi1, Melike Sezgin Evim2
1Uludag University Faculty of Medicine, Department of Pediatric Infectious Diseases, Bursa, Turkey.
Mikrobiyoloji Bulteni
|February 14, 2020
Summary
Micafungin is a safe and effective antifungal for pediatric patients, including newborns, especially those with liver or kidney issues. This study found it well-tolerated and effective in treating invasive fungal infections in children.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology
- Critical Care Medicine
Background:
- Micafungin is recommended for invasive candidiasis, particularly in patients with compromised liver or kidney function.
- Pediatric patients, especially those in intensive care units, often present with complex medical conditions and risk factors for fungal infections.
Purpose of the Study:
- To retrospectively evaluate the safety and efficacy of micafungin treatment in a cohort of hospitalized pediatric patients.
- To assess clinical outcomes, laboratory values, and adverse events associated with micafungin use in children.
Main Methods:
- Retrospective analysis of 125 pediatric patients treated with micafungin between November 2016 and January 2019.
- Evaluation of clinical data, indications for micafungin, blood values, and side effects.
Main Results:
- Micafungin treatment led to significant decreases in C-reactive protein and alanine aminotransferase, and an increase in sodium levels.
- Patients with prior antifungal-induced hypokalemia showed normalization of potassium levels after micafungin.
- No significant micafungin-related side effects were observed, indicating a favorable safety profile.
Conclusions:
- Micafungin is a safe and effective treatment option for pediatric patients, including neonates, with invasive fungal infections.
- The drug is particularly beneficial for children with elevated liver and kidney function tests, and those experiencing side effects from other antifungals.
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