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Bone health in bipolar disorder: a study protocol for a case-control study in Australia
Lana J Williams1,2, Amanda L Stuart3, Michael Berk3,4,5,6
1School of Medicine, Deakin University, Geelong, Victoria, Australia l.williams@deakin.edu.au.
BMJ Open
|February 14, 2020
Summary
This study investigates bone health in adults with bipolar disorder, comparing ~200 cases to ~1500 controls to assess bipolar disorder as a risk factor for bone fragility.
Area of Science:
- Psychiatry
- Osteoporosis Research
- Bone Health
Background:
- Limited data exists on bone health in adults with bipolar disorder.
- Existing evidence suggests potential bone deficits in individuals with other mental illnesses or on common bipolar disorder medications.
Purpose of the Study:
- To examine bipolar disorder as a risk factor for bone fragility.
- To present the methodology of a case-control study designed to investigate this relationship.
Main Methods:
- A case-control study comparing ~200 adults with bipolar disorder to ~1500 controls from the Geelong Osteoporosis Study.
- Utilizing the Structured Clinical Interview for DSM-IV-TR, validated rating scales, questionnaires, and dual-energy X-ray absorptiometry (DXA) scans.
- Collecting demographic, lifestyle, and medical history data, alongside bone and body composition measurements and blood samples.
Main Results:
- Methodology for a case-control study is presented.
- The study aims to recruit and compare cases and controls.
Conclusions:
- The study will provide insights into the association between bipolar disorder and bone fragility.
- Findings will be disseminated through publications and presentations.
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