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Intravoxel incoherent motion imaging using steady-state free precession

D Le Bihan1

  • 1Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892.

Magnetic Resonance in Medicine
|July 1, 1988
PubMed

Insights

A new steady-state free precession (SSFP) method significantly speeds up intravoxel incoherent motion (IVIM) imaging. This faster SSFP technique shows greater sensitivity for IVIM compared to traditional spin-echo methods.

Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Medical Physics

Background:

  • Intravoxel incoherent motion (IVIM) MR imaging provides in vivo diffusion and perfusion data.
  • Conventional IVIM imaging utilizes spin-echo sequences, leading to lengthy acquisition times (over 17 minutes).

Purpose of the Study:

  • To introduce a novel, rapid method for acquiring IVIM MR images.
  • To evaluate the performance of the new method compared to existing techniques.

Main Methods:

  • Development and application of a steady-state free precession (SSFP) sequence for IVIM acquisition.
  • Comparison of SSFP-based IVIM with spin-echo based IVIM using phantom studies.
  • Validation with in vivo imaging.

Main Results:

  • The proposed SSFP method enables IVIM image acquisition in significantly reduced time (a few minutes).
  • Phantom studies demonstrated superior sensitivity of SSFP to IVIM parameters compared to spin-echo sequences.
  • Successful in vivo imaging was achieved using the SSFP-based approach.

Conclusions:

  • SSFP is a promising technique for accelerating IVIM MR imaging.
  • The enhanced sensitivity and speed of SSFP offer potential advantages for clinical applications of IVIM.

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