Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A general approach to selection of multiple cubic volume elements using the ISIS technique.

R J Ordidge1, R M Bowley, G McHale

  • 1Department of Physics, University of Nottingham, United Kingdom.

Magnetic Resonance in Medicine
|November 1, 1988
PubMed
Summary

The In Vivo Spectroscopic Selection (ISIS) method now allows selecting multiple tissue volumes simultaneously for high-resolution NMR spectroscopy. This advanced technique improves signal-to-noise ratio by co-adding signals from selected regions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-traumatic stress disorder cases reported by UK occupational physicians 1996-2024.

Occupational medicine (Oxford, England)·2026
Same author

Evaporation and Electrowetting of Sessile Droplets on Slippery Liquid-Like Surfaces and Slippery Liquid-Infused Porous Surfaces (SLIPS).

Langmuir : the ACS journal of surfaces and colloids·2020
Same author

Reduced Thermodynamic Description of Phase Separation in a Quasi-One-Dimensional Granular Gas.

Physical review letters·2019
Same author

Bimorph material/structure designs for high sensitivity flexible surface acoustic wave temperature sensors.

Scientific reports·2018
Same author

The minimization of mechanical work in vibrated granular matter.

Scientific reports·2016
Same author

Propulsion of a Two-Sphere Swimmer.

Physical review letters·2015

Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • In Vivo Imaging
  • Biomedical Engineering

Background:

  • The ISIS method is a standard technique for selecting single cubic volumes of tissue for in vivo high-resolution NMR spectroscopy.
  • Current limitations restrict ISIS to analyzing one tissue volume at a time.

Purpose of the Study:

  • To extend the ISIS method for simultaneous selection of multiple cubic tissue volumes.
  • To enable individual assessment or co-addition of signals from multiple volumes.
  • To enhance signal-to-noise ratio in localized NMR spectra.

Main Methods:

  • Theoretical extension of the ISIS technique.
  • Inclusion of additional selective radiofrequency (RF) pulses in the spatial encoding prepulse period.
  • Spatially localized spectra generated through addition and subtraction of NMR signals, analogous to the original ISIS method.

Related Experiment Videos

Main Results:

  • Demonstrated the theoretical feasibility of simultaneously selecting multiple cubic volumes.
  • Showcased the potential for individual signal assessment or signal co-addition.
  • Indicated improvement in signal-to-noise ratio through signal co-addition.

Conclusions:

  • The modified ISIS technique successfully extends multi-volume selection for in vivo NMR spectroscopy.
  • This advancement offers improved data acquisition efficiency and signal quality.
  • The method retains the core principles of spatial localization through signal manipulation.