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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
281
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

228
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
228
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

243
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Updated: Dec 28, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Lessons learned from kidney dysfunction : Preventing organ failure.

Stefan John1

  • 1Medical Intensive Care, Medical Department 8, Klinikum Nuernberg-Sued, Paracelsus Medical University and University of Erlangen-Nuernberg, Breslauerstr. 201, 90471, Nuernberg, Germany. Stefan.John@klinikum-nuernberg.de.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|February 14, 2020
PubMed
Summary
This summary is machine-generated.

Acute kidney injury (AKI) management has evolved, emphasizing early risk identification and hemodynamic stabilization. New insights suggest vasoconstrictors, not vasodilators, and restrictive fluid therapy are beneficial for renal protection in critically ill patients.

Keywords:
Acute kidney injuryFluid therapyHemodynamic stabilizationSepsisVasopressors

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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Intensive Care Unit (ICU) Management

Background:

  • Acute kidney injury (AKI) is a frequent and severe complication in ICU patients, significantly impacting mortality and morbidity.
  • Effective renal protective strategies are crucial for managing critically ill patients.

Purpose of the Study:

  • To review evolving concepts in AKI prevention and therapy.
  • To highlight recent findings that have reversed or modified previous understandings of AKI pathophysiology and treatment.

Main Methods:

  • Review of recent pathophysiologic concepts and clinical research in AKI.
  • Analysis of updated preventive and therapeutic strategies for AKI.

Main Results:

  • Early identification of patients at risk and hemodynamic stabilization are key to renal protection.
  • Recent research refutes renal ischemia due to vasoconstriction; septic AKI involves increased renal blood flow and intrarenal vasodilation.
  • Vasoconstrictors, not vasodilators, are now considered beneficial; a mean arterial pressure >65 mmHg is often recommended, with higher targets for hypertensive patients.
  • Restrictive fluid therapy with balanced crystalloids is gaining importance; anti-inflammatory strategies targeting inflammation and mitochondrial dysfunction are under investigation.

Conclusions:

  • AKI management requires a paradigm shift based on new pathophysiologic insights.
  • Future AKI prevention and therapy may focus on anti-inflammatory approaches and precise hemodynamic management.